Increasing Incidence Of Coagulase - Negative Staphylococcal Sepsis - An Emerging Challenges
نویسندگان
چکیده
IntroductionCoagulase negative Staphylococcus (CoNS), being a part of the commensal flora, have long remained neglected as mere contaminants till their recently reported increased rate of isolation, evidenced their potential as nosocomial pathogens. Treatment is difficult due to confusion in pathogenecity and multi-drug resistance. Aim of the study was to to identify the different species of CoNS from blood sample of patients having signs and symptoms of septicaemia and to establish their clinical relevance. Material and Method: Blood cultures were processed in BacT/Alert 3-D system (BioMerioux). One hundred fifty three (153) CoNS were isolated from blood culture of different age group patients. A few samples were tested by Microscan autoSCAN4. Biotyping includes coagulase test (both slide and tube), nitrate reduction test, urease test, ONPG test. Disc diffusion tests include polymyxin-B, Bacitracin, novobiocin discs. Tests for bioflim production were carried out by Congo Red Agar (CRA) method and Tube method (TM). Finally antibiotic sensitivity testing was carried out by disc-diffusion method of Kirby-Bauer. Result: 153 CoNS were isolated in period of six months from sepsis patients. Number of S.epidermidis (25%) was highest among them followed by S.haemolyticus (14%). Most of them (85%) are bioflim producer. Conclusion: This will most accurately promote treatment for those patients with true CoNS infection. It will also avoid unnecessary treatment in those without true infection.
منابع مشابه
A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units.
OBJECTIVE To study late onset systemic infections with coagulase negative staphylococci. METHODS Prospective longitudinal study of coagulase negative staphylococcal infection in 18 Australasian neonatal nurseries. RESULTS From 1991 to 2000 inclusive, there were 1281 cases of coagulase negative staphylococcal (CoNS) sepsis, comprising 57.1% of all late onset infections. The male/female ratio...
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